Endocrine Abstracts

The DCCT conclusively confirmed that long-term microvascular complications of Type 1 diabetes can be prevented by restoration of near-normal glucose levels. Despite ongoing refinements in management including structured re-education, optimized insulin analogue regimens, continuous subcutaneous insulin infusion and even steps towards the bioartificial pancreas, exogenous insulin replacement is inextricably linked to risk of severe hypoglycaemia.Transplant...

Objectives: To define clinical and metabolic factors associated with severe hypoglycaemia (SH) in affected individuals with Type 1 diabetes (T1DM).Methods: Individuals with T1DM and SH (defined as hypoglycaemia requiring third party intervention within the preceding 12 months) were characterised to include screening for other underlying autoimmune disease (coeliac serology, short synacthen and thyroid function tests); a questionnaire to evaluate underlyi...

Background: The polycystic ovary syndrome (PCOS) is a condition defined by hyperandrogenism and ovulatory dysfunction. It is also known to be associated with insulin resistance and has many features in common with the metabolic syndrome (MS) - a cluster of risk factors that have been shown to predict a greater risk of future cardiovascular events and type 2 diabetes. While there are studies confirming that the MS is more common in PCOS, none have systematically compared the re...

Objective: To compare clinical characteristics in individuals with established Type 1 diabetes mellitus with and without altered hypoglycaemia unawareness (AHA) / severe hypoglycaemia (SH).Methods: Individuals with AHA and/or SH and controls matched for age, sex and duration of diabetes but with no history of AHA or SH were identified from databases of those attending the Newcastle Diabetes centre with Type 1 diabetes. Characteristics were confirmed from...

Aims: To compare glycaemic control and weight gain in children with type 1 diabetes changing from twice daily premixed insulin to multiple daily injections (MDI) with either insulin glargine or insulin detemir.Methods: A retrospective study of 41 consecutive children and adolescents with type 1 diabetes, changed to MDI between January 2005 and April 2007, with outcome measures of HbA1C change and body mass index SDS (BMI-SDS) change after 12 months of MD...

Introduction: Timing, extent, complications rate and long term results of paediatric prophylactic thyroidectomy (pPT) for MEN2 in the UK are unknown.Methods: All UK centers performing pPT were invited to participate in the study.Data were obtained from notes and hospitals electronic databases.Results: Fifty-one children (27 males) were included.All had genetic test at the mean age of 5 years (median 3, range 0.25–15), confirmi...